About

Synthetic biology represents a paradigm shift – biology is becoming an engineering discipline that aims to use engineering principles to design and construct cells and organisms with novel functions.

Overview

The CelESTial project is a partnership between the Estonian Centre for Synthetic Biology (ECSB) at the University of Tartu and the Novo Nordisk Foundation Centre for Biosustainability at the Technical University of Denmark. Our main aim is to create a research and development platform for the sustainable bio-manufacturing of high value chemicals and pharmaceuticals using cell factories.

Objective

The cell factory platform being developed for the sustainable bio-manufacturing of high value chemicals and pharmaceuticals will rely on the concerted action of both centres, and their industrial partners, and will accelerate the transition from proof-of-concept science to commercial production via iterative design cycles. The platform will move cell factory technology from the lab to pilot-scale production in bioreactors with less cost and development time compared with current techniques. One of the new emerging technologies developed in ECSB is the first syntehtic biology toolbox for design of synthetic signaling circuits based on multisite phosphorylation of protein tags by protein kinases developed under the ERC Consolidator grant, led by Prof. Mart Loog. These synthetic circuits will be used for modlation of metabolic pathway activities in cell factory producer strains.

Education & Outreach

The ECSB initiated the development of international curricula in synthetic biology that has become a fully operational programme. We have established innovative Master’s and PhD programs in synthetic biology, led by program Dr. Ilona Faustova and prof. Mart Loog in close collaboration with the molecular biology and engineering laboratories within the centre. The labour needs and expectations of industry are currently being identified and taken into account in the curricula building process.

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{:gb}Our Story{:}{:ee}Meie Lugu{:}

{:gb}The Estonian Centre for Synthetic Biology was founded in spring 2016 on the basis of the Institute of Technology (www.tuit.ut.ee), University of Tartu (www.ut.ee), and a collection of other Estonian labs that conduct research on various aspects of synthetic biology. The leading figures of the initiative were prof. Mart Loog (looglab.com) and newly appointed ERA Chair holder in synthetic biology Dr. Petri –Jan Lahtvee. The ECSB, while founded and based at the Institute of Technology, is currently acting as an umbrella organization for the consortium of synthetic biology labs in Estonia, but its greater aim is to develop a research and technology development centre of its own.{:}{:ee}Eesti Sünteetilise Bioloogia Keskus asutati 2016. aasta kevadel Tehnoloogiainstituudi baasil (www.tuit.ut .ee), Tartu Ülikooli (www.ut.ee) ja kogu teised Eesti laborid, mis tegelevad sünteetilise bioloogia eri aspektide uurimisega. Algatuse juhtfiguurid olid prof. Mart Loog (looglab.com) ja äsja ametisse nimetatud ERA sünteetilise bioloogia õppetooli hoidja dr Petri –Jan Lahtvee. Tehnoloogiainstituudis asutatud ja seal tegutsev EKSP tegutseb praegu sünteetilise bioloogia laborite konsortsiumi katusorganisatsioonina Eestis, kuid selle suurem eesmärk on arendada välja oma teadus- ja tehnoloogiaarenduskeskus.{:}

Our Team

Mart Loog
Mart Loog
Professor in Molecular Systems Biology
Ilona Faustova
Ilona Faustova
Account Manager
Petri Lahtvee
Petri Lahtvee
Senior Scientist/Group leader

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